Click here to close now.




















Welcome!

Open Source Cloud Authors: Tim Hinds, Kevin Benedict, Jim Taylor, Pat Romanski, Liz McMillan

News Feed Item

Importante paso adelante en la investigación sobre la osteoartritis

- Importante paso adelante en la investigación sobre la osteoartritis: los péptidos con colágeno bioactivos estimulan la regeneración de los tejidos de los cartílagos

MONTREAL y KIEL, Alemania, September 14 /PRNewswire/ -- Trabajando en colaboración con la Kiel University, los investigadores del Collagen Research Institute (CRI), con sede en Kiel, han demostrado el efecto estimulador de los péptidos de colágeno bioactivos especiales (FORTIGEL(R)) en el contexto de los experimentos celulares. La semana pasada, el CRI presentó los descubrimientos de sus investigaciones en el Congreso de la Osteoarthritis Research Society International (OARSI) celebrado en Montreal. Las investigaciones del CRI proporcionan una explicación para los descubrimientos en los ensayos clínicos conjuntos realizados en la Harvard Medical School y el Tufts Medical Center, tal y como se han presentado en el congreso. Con la ayuda de las técnicas de imágenes especiales (MRI), este ensayo ha demostrado que el metabolismo celular estimulado FORTIGEL(R) en los cartílagos de las articulaciones de las rodillas y promueve la regeneración del tejido de los cartílagos.

En cooperación con la Kiel University, los investigadores del CRI han aplicado los métodos de biología molecular y química de proteínas directamente en las células, a fin de demostrar el efecto estimulador de FORTIGEL(R). Desarrollado por GELITA AG, este producto contiene una combinación especial de péptidos de colágeno bioactivos de alta pureza. "En todas nuestras investigaciones hemos demostrado que, junto a la síntesis del colágeno de Tipo II - FORTIGEL(R) induce el aumento de producción de aggrecan, un proteoglicanos especial que es de vital importancia para la función de los cartílagos", explicó el doctor Steffen Oesser, director del CRI. Esto proporciona una prueba experimental de que la aplicación de los péptidos de colágeno bioactivos estimula la síntesis renovada de la matriz de los cartílagos extracelulares.

El experimento celular subraya el estudio clínico de Harvard/Tufts

Los experimentos basados en las células del CRI confirman los descubrimientos de los ensayos realizados en la Harvard Medical School y el Tufts Medical Center. El CRI ha demostrado de forma clara a nivel celular que FORTIGEL(R) proporciona un aumento del proteoglicano. Anteriormente, los ensayos clínicos de Harvard/Tufts habían demostrado el efecto regenerativo de FORTIGEL(R) en los cartílagos de las articulaciones de rodilla utilizando la técnica de la imagen de objetivos. Estas dos investigaciones se complementan entre ellas.

El ensayo doble ciego controlado por placebo de Harvard/Tufts reclutó a 30 pacientes diagnosticados con osteoartritis de rodilla, revelando una regeneración destacada del tejido de los cartílagos en el grupo de tratamiento basado en FORTIGEL(R). Dentro del grupo tratado con placebo, la degeneración del cartílago progreso igual que antes.

Para analizar los cambios estructurales en el tejido de los cartílagos, los investigadores de Harvard/Tufts desplegaron una técnica de imagen especial (dGEMRIC). Tras la inyección de un tinte especial en la articulación de la rodilla del paciente es posible determinar la densidad de los proteoglicanos en el cartílago con un alto grado de precisión. Los resultados de este ensayo clínico indican un aumento considerable del proteoglicanos tras la aplicación de FORTIGEL(R). Esto sirve como confirmación clínica de los descubrimientos experimentales del CRI.

Tratamiento de la osteoartritis

"La manipulación prevista del metabolismo del cartílago abre nuevas posibilidades para el tratamiento y la prevención de la osteoartritis", enfatizó el doctor Oesser. Al contrario que los analgésicos y los fármacos antirreumáticos, que apenas alivian los síntomas y efectos, FORTIGEL(R) ofrece el potencial de una terapia alimentaria casual.

Existe una cifra mundial de unos 135 millones de personas que padecen osteoartritis. Los expertos han previsto un rápido aumento de esta cifra, sobre todo en los países industrializados. La prevención de las enfermedades artríticas tiene una prioridad absoluta, principalmente por los elevados costes que supone para los sistemas sanitarios.

Con sede en Kiel/Alemania, el Collagen Research Institute (CRI) se creó en 2003 como organización de investigación independiente. Las actividades del instituto se centran en los cambios degenerativos de los tejidos de conexión y el desarrollo de terapias complementarias y alternativas en el área de la osteoartritis, osteoporosis y cicatrización de heridas. Desde su creación, el CRI ha puesto una atención especial a la investigación de los efectos de los péptidos de colágeno en la matriz extracelular del cartílago articular.

    
    Collagen Research Institute
    Doctor Steffen Oesser
    Tel. +49-(0)431-56-06-610
    Fax  +49-(0)431-56-06-613
    [email protected]

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
For IoT to grow as quickly as analyst firms’ project, a lot is going to fall on developers to quickly bring applications to market. But the lack of a standard development platform threatens to slow growth and make application development more time consuming and costly, much like we’ve seen in the mobile space. In his session at @ThingsExpo, Mike Weiner, Product Manager of the Omega DevCloud with KORE Telematics Inc., discussed the evolving requirements for developers as IoT matures and conducted a live demonstration of how quickly application development can happen when the need to comply wit...
The Internet of Everything (IoE) brings together people, process, data and things to make networked connections more relevant and valuable than ever before – transforming information into knowledge and knowledge into wisdom. IoE creates new capabilities, richer experiences, and unprecedented opportunities to improve business and government operations, decision making and mission support capabilities.
Explosive growth in connected devices. Enormous amounts of data for collection and analysis. Critical use of data for split-second decision making and actionable information. All three are factors in making the Internet of Things a reality. Yet, any one factor would have an IT organization pondering its infrastructure strategy. How should your organization enhance its IT framework to enable an Internet of Things implementation? In his session at @ThingsExpo, James Kirkland, Red Hat's Chief Architect for the Internet of Things and Intelligent Systems, described how to revolutionize your archit...
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
MuleSoft has announced the findings of its 2015 Connectivity Benchmark Report on the adoption and business impact of APIs. The findings suggest traditional businesses are quickly evolving into "composable enterprises" built out of hundreds of connected software services, applications and devices. Most are embracing the Internet of Things (IoT) and microservices technologies like Docker. A majority are integrating wearables, like smart watches, and more than half plan to generate revenue with APIs within the next year.
Growth hacking is common for startups to make unheard-of progress in building their business. Career Hacks can help Geek Girls and those who support them (yes, that's you too, Dad!) to excel in this typically male-dominated world. Get ready to learn the facts: Is there a bias against women in the tech / developer communities? Why are women 50% of the workforce, but hold only 24% of the STEM or IT positions? Some beginnings of what to do about it! In her Opening Keynote at 16th Cloud Expo, Sandy Carter, IBM General Manager Cloud Ecosystem and Developers, and a Social Business Evangelist, d...
In his keynote at 16th Cloud Expo, Rodney Rogers, CEO of Virtustream, discussed the evolution of the company from inception to its recent acquisition by EMC – including personal insights, lessons learned (and some WTF moments) along the way. Learn how Virtustream’s unique approach of combining the economics and elasticity of the consumer cloud model with proper performance, application automation and security into a platform became a breakout success with enterprise customers and a natural fit for the EMC Federation.
The Internet of Things is not only adding billions of sensors and billions of terabytes to the Internet. It is also forcing a fundamental change in the way we envision Information Technology. For the first time, more data is being created by devices at the edge of the Internet rather than from centralized systems. What does this mean for today's IT professional? In this Power Panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists addressed this very serious issue of profound change in the industry.
Discussions about cloud computing are evolving into discussions about enterprise IT in general. As enterprises increasingly migrate toward their own unique clouds, new issues such as the use of containers and microservices emerge to keep things interesting. In this Power Panel at 16th Cloud Expo, moderated by Conference Chair Roger Strukhoff, panelists addressed the state of cloud computing today, and what enterprise IT professionals need to know about how the latest topics and trends affect their organization.
It is one thing to build single industrial IoT applications, but what will it take to build the Smart Cities and truly society-changing applications of the future? The technology won’t be the problem, it will be the number of parties that need to work together and be aligned in their motivation to succeed. In his session at @ThingsExpo, Jason Mondanaro, Director, Product Management at Metanga, discussed how you can plan to cooperate, partner, and form lasting all-star teams to change the world and it starts with business models and monetization strategies.
Converging digital disruptions is creating a major sea change - Cisco calls this the Internet of Everything (IoE). IoE is the network connection of People, Process, Data and Things, fueled by Cloud, Mobile, Social, Analytics and Security, and it represents a $19Trillion value-at-stake over the next 10 years. In her keynote at @ThingsExpo, Manjula Talreja, VP of Cisco Consulting Services, discussed IoE and the enormous opportunities it provides to public and private firms alike. She will share what businesses must do to thrive in the IoE economy, citing examples from several industry sectors.
There will be 150 billion connected devices by 2020. New digital businesses have already disrupted value chains across every industry. APIs are at the center of the digital business. You need to understand what assets you have that can be exposed digitally, what their digital value chain is, and how to create an effective business model around that value chain to compete in this economy. No enterprise can be complacent and not engage in the digital economy. Learn how to be the disruptor and not the disruptee.
Akana has released Envision, an enhanced API analytics platform that helps enterprises mine critical insights across their digital eco-systems, understand their customers and partners and offer value-added personalized services. “In today’s digital economy, data-driven insights are proving to be a key differentiator for businesses. Understanding the data that is being tunneled through their APIs and how it can be used to optimize their business and operations is of paramount importance,” said Alistair Farquharson, CTO of Akana.
Business as usual for IT is evolving into a "Make or Buy" decision on a service-by-service conversation with input from the LOBs. How does your organization move forward with cloud? In his general session at 16th Cloud Expo, Paul Maravei, Regional Sales Manager, Hybrid Cloud and Managed Services at Cisco, discusses how Cisco and its partners offer a market-leading portfolio and ecosystem of cloud infrastructure and application services that allow you to uniquely and securely combine cloud business applications and services across multiple cloud delivery models.
The enterprise market will drive IoT device adoption over the next five years. In his session at @ThingsExpo, John Greenough, an analyst at BI Intelligence, division of Business Insider, analyzed how companies will adopt IoT products and the associated cost of adopting those products. John Greenough is the lead analyst covering the Internet of Things for BI Intelligence- Business Insider’s paid research service. Numerous IoT companies have cited his analysis of the IoT. Prior to joining BI Intelligence, he worked analyzing bank technology for Corporate Insight and The Clearing House Payment...
"Optimal Design is a technology integration and product development firm that specializes in connecting devices to the cloud," stated Joe Wascow, Co-Founder & CMO of Optimal Design, in this SYS-CON.tv interview at @ThingsExpo, held June 9-11, 2015, at the Javits Center in New York City.
SYS-CON Events announced today that CommVault has been named “Bronze Sponsor” of SYS-CON's 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. A singular vision – a belief in a better way to address current and future data management needs – guides CommVault in the development of Singular Information Management® solutions for high-performance data protection, universal availability and simplified management of data on complex storage networks. CommVault's exclusive single-platform architecture gives companies unp...
Electric Cloud and Arynga have announced a product integration partnership that will bring Continuous Delivery solutions to the automotive Internet-of-Things (IoT) market. The joint solution will help automotive manufacturers, OEMs and system integrators adopt DevOps automation and Continuous Delivery practices that reduce software build and release cycle times within the complex and specific parameters of embedded and IoT software systems.
"ciqada is a combined platform of hardware modules and server products that lets people take their existing devices or new devices and lets them be accessible over the Internet for their users," noted Geoff Engelstein of ciqada, a division of Mars International, in this SYS-CON.tv interview at @ThingsExpo, held June 9-11, 2015, at the Javits Center in New York City.
Internet of Things is moving from being a hype to a reality. Experts estimate that internet connected cars will grow to 152 million, while over 100 million internet connected wireless light bulbs and lamps will be operational by 2020. These and many other intriguing statistics highlight the importance of Internet powered devices and how market penetration is going to multiply many times over in the next few years.