Welcome!

Open Source Cloud Authors: Elizabeth White, Yeshim Deniz, Pat Romanski, Liz McMillan, Carmen Gonzalez

News Feed Item

Importante paso adelante en la investigación sobre la osteoartritis

- Importante paso adelante en la investigación sobre la osteoartritis: los péptidos con colágeno bioactivos estimulan la regeneración de los tejidos de los cartílagos

MONTREAL y KIEL, Alemania, September 14 /PRNewswire/ -- Trabajando en colaboración con la Kiel University, los investigadores del Collagen Research Institute (CRI), con sede en Kiel, han demostrado el efecto estimulador de los péptidos de colágeno bioactivos especiales (FORTIGEL(R)) en el contexto de los experimentos celulares. La semana pasada, el CRI presentó los descubrimientos de sus investigaciones en el Congreso de la Osteoarthritis Research Society International (OARSI) celebrado en Montreal. Las investigaciones del CRI proporcionan una explicación para los descubrimientos en los ensayos clínicos conjuntos realizados en la Harvard Medical School y el Tufts Medical Center, tal y como se han presentado en el congreso. Con la ayuda de las técnicas de imágenes especiales (MRI), este ensayo ha demostrado que el metabolismo celular estimulado FORTIGEL(R) en los cartílagos de las articulaciones de las rodillas y promueve la regeneración del tejido de los cartílagos.

En cooperación con la Kiel University, los investigadores del CRI han aplicado los métodos de biología molecular y química de proteínas directamente en las células, a fin de demostrar el efecto estimulador de FORTIGEL(R). Desarrollado por GELITA AG, este producto contiene una combinación especial de péptidos de colágeno bioactivos de alta pureza. "En todas nuestras investigaciones hemos demostrado que, junto a la síntesis del colágeno de Tipo II - FORTIGEL(R) induce el aumento de producción de aggrecan, un proteoglicanos especial que es de vital importancia para la función de los cartílagos", explicó el doctor Steffen Oesser, director del CRI. Esto proporciona una prueba experimental de que la aplicación de los péptidos de colágeno bioactivos estimula la síntesis renovada de la matriz de los cartílagos extracelulares.

El experimento celular subraya el estudio clínico de Harvard/Tufts

Los experimentos basados en las células del CRI confirman los descubrimientos de los ensayos realizados en la Harvard Medical School y el Tufts Medical Center. El CRI ha demostrado de forma clara a nivel celular que FORTIGEL(R) proporciona un aumento del proteoglicano. Anteriormente, los ensayos clínicos de Harvard/Tufts habían demostrado el efecto regenerativo de FORTIGEL(R) en los cartílagos de las articulaciones de rodilla utilizando la técnica de la imagen de objetivos. Estas dos investigaciones se complementan entre ellas.

El ensayo doble ciego controlado por placebo de Harvard/Tufts reclutó a 30 pacientes diagnosticados con osteoartritis de rodilla, revelando una regeneración destacada del tejido de los cartílagos en el grupo de tratamiento basado en FORTIGEL(R). Dentro del grupo tratado con placebo, la degeneración del cartílago progreso igual que antes.

Para analizar los cambios estructurales en el tejido de los cartílagos, los investigadores de Harvard/Tufts desplegaron una técnica de imagen especial (dGEMRIC). Tras la inyección de un tinte especial en la articulación de la rodilla del paciente es posible determinar la densidad de los proteoglicanos en el cartílago con un alto grado de precisión. Los resultados de este ensayo clínico indican un aumento considerable del proteoglicanos tras la aplicación de FORTIGEL(R). Esto sirve como confirmación clínica de los descubrimientos experimentales del CRI.

Tratamiento de la osteoartritis

"La manipulación prevista del metabolismo del cartílago abre nuevas posibilidades para el tratamiento y la prevención de la osteoartritis", enfatizó el doctor Oesser. Al contrario que los analgésicos y los fármacos antirreumáticos, que apenas alivian los síntomas y efectos, FORTIGEL(R) ofrece el potencial de una terapia alimentaria casual.

Existe una cifra mundial de unos 135 millones de personas que padecen osteoartritis. Los expertos han previsto un rápido aumento de esta cifra, sobre todo en los países industrializados. La prevención de las enfermedades artríticas tiene una prioridad absoluta, principalmente por los elevados costes que supone para los sistemas sanitarios.

Con sede en Kiel/Alemania, el Collagen Research Institute (CRI) se creó en 2003 como organización de investigación independiente. Las actividades del instituto se centran en los cambios degenerativos de los tejidos de conexión y el desarrollo de terapias complementarias y alternativas en el área de la osteoartritis, osteoporosis y cicatrización de heridas. Desde su creación, el CRI ha puesto una atención especial a la investigación de los efectos de los péptidos de colágeno en la matriz extracelular del cartílago articular.

    
    Collagen Research Institute
    Doctor Steffen Oesser
    Tel. +49-(0)431-56-06-610
    Fax  +49-(0)431-56-06-613
    [email protected]

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
The 20th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held June 6-8, 2017, at the Javits Center in New York City, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit your speaking proposal ...
You have great SaaS business app ideas. You want to turn your idea quickly into a functional and engaging proof of concept. You need to be able to modify it to meet customers' needs, and you need to deliver a complete and secure SaaS application. How could you achieve all the above and yet avoid unforeseen IT requirements that add unnecessary cost and complexity? You also want your app to be responsive in any device at any time. In his session at 19th Cloud Expo, Mark Allen, General Manager of...
The Internet of Things (IoT) promises to simplify and streamline our lives by automating routine tasks that distract us from our goals. This promise is based on the ubiquitous deployment of smart, connected devices that link everything from industrial control systems to automobiles to refrigerators. Unfortunately, comparatively few of the devices currently deployed have been developed with an eye toward security, and as the DDoS attacks of late October 2016 have demonstrated, this oversight can ...
"ReadyTalk is an audio and web video conferencing provider. We've really come to embrace WebRTC as the platform for our future of technology," explained Dan Cunningham, CTO of ReadyTalk, in this SYS-CON.tv interview at WebRTC Summit at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Major trends and emerging technologies – from virtual reality and IoT, to Big Data and algorithms – are helping organizations innovate in the digital era. However, to create real business value, IT must think beyond the ‘what’ of digital transformation to the ‘how’ to harness emerging trends, innovation and disruption. Architecture is the key that underpins and ties all these efforts together. In the digital age, it’s important to invest in architecture, extend the enterprise footprint to the cl...
Bert Loomis was a visionary. This general session will highlight how Bert Loomis and people like him inspire us to build great things with small inventions. In their general session at 19th Cloud Expo, Harold Hannon, Architect at IBM Bluemix, and Michael O'Neill, Strategic Business Development at Nvidia, discussed the accelerating pace of AI development and how IBM Cloud and NVIDIA are partnering to bring AI capabilities to "every day," on-demand. They also reviewed two "free infrastructure" pr...
"Dice has been around for the last 20 years. We have been helping tech professionals find new jobs and career opportunities," explained Manish Dixit, VP of Product and Engineering at Dice, in this SYS-CON.tv interview at 19th Cloud Expo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
More and more brands have jumped on the IoT bandwagon. We have an excess of wearables – activity trackers, smartwatches, smart glasses and sneakers, and more that track seemingly endless datapoints. However, most consumers have no idea what “IoT” means. Creating more wearables that track data shouldn't be the aim of brands; delivering meaningful, tangible relevance to their users should be. We're in a period in which the IoT pendulum is still swinging. Initially, it swung toward "smart for smar...
Extracting business value from Internet of Things (IoT) data doesn’t happen overnight. There are several requirements that must be satisfied, including IoT device enablement, data analysis, real-time detection of complex events and automated orchestration of actions. Unfortunately, too many companies fall short in achieving their business goals by implementing incomplete solutions or not focusing on tangible use cases. In his general session at @ThingsExpo, Dave McCarthy, Director of Products...
Successful digital transformation requires new organizational competencies and capabilities. Research tells us that the biggest impediment to successful transformation is human; consequently, the biggest enabler is a properly skilled and empowered workforce. In the digital age, new individual and collective competencies are required. In his session at 19th Cloud Expo, Bob Newhouse, CEO and founder of Agilitiv, drew together recent research and lessons learned from emerging and established compa...
Businesses and business units of all sizes can benefit from cloud computing, but many don't want the cost, performance and security concerns of public cloud nor the complexity of building their own private clouds. Today, some cloud vendors are using artificial intelligence (AI) to simplify cloud deployment and management. In his session at 20th Cloud Expo, Ajay Gulati, Co-founder and CEO of ZeroStack, will discuss how AI can simplify cloud operations. He will cover the following topics: why clou...
The WebRTC Summit New York, to be held June 6-8, 2017, at the Javits Center in New York City, NY, announces that its Call for Papers is now open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 20th International Cloud Expo and @ThingsExpo. WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web ...
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
20th Cloud Expo, taking place June 6-8, 2017, at the Javits Center in New York City, NY, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy.
WebRTC is the future of browser-to-browser communications, and continues to make inroads into the traditional, difficult, plug-in web communications world. The 6th WebRTC Summit continues our tradition of delivering the latest and greatest presentations within the world of WebRTC. Topics include voice calling, video chat, P2P file sharing, and use cases that have already leveraged the power and convenience of WebRTC.
Amazon has gradually rolled out parts of its IoT offerings, but these are just the tip of the iceberg. In addition to optimizing their backend AWS offerings, Amazon is laying the ground work to be a major force in IoT - especially in the connected home and office. In his session at @ThingsExpo, Chris Kocher, founder and managing director of Grey Heron, explained how Amazon is extending its reach to become a major force in IoT by building on its dominant cloud IoT platform, its Dash Button strat...
Internet-of-Things discussions can end up either going down the consumer gadget rabbit hole or focused on the sort of data logging that industrial manufacturers have been doing forever. However, in fact, companies today are already using IoT data both to optimize their operational technology and to improve the experience of customer interactions in novel ways. In his session at @ThingsExpo, Gordon Haff, Red Hat Technology Evangelist, will share examples from a wide range of industries – includin...
"We build IoT infrastructure products - when you have to integrate different devices, different systems and cloud you have to build an application to do that but we eliminate the need to build an application. Our products can integrate any device, any system, any cloud regardless of protocol," explained Peter Jung, Chief Product Officer at Pulzze Systems, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
The cloud promises new levels of agility and cost-savings for Big Data, data warehousing and analytics. But it’s challenging to understand all the options – from IaaS and PaaS to newer services like HaaS (Hadoop as a Service) and BDaaS (Big Data as a Service). In her session at @BigDataExpo at @ThingsExpo, Hannah Smalltree, a director at Cazena, provided an educational overview of emerging “as-a-service” options for Big Data in the cloud. This is critical background for IT and data professionals...
"Once customers get a year into their IoT deployments, they start to realize that they may have been shortsighted in the ways they built out their deployment and the key thing I see a lot of people looking at is - how can I take equipment data, pull it back in an IoT solution and show it in a dashboard," stated Dave McCarthy, Director of Products at Bsquare Corporation, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.