Welcome!

Open Source Cloud Authors: Jayaram Krishnaswamy, Derek Weeks, Anders Wallgren, Elizabeth White, Dana Gardner

News Feed Item

Importante paso adelante en la investigación sobre la osteoartritis

- Importante paso adelante en la investigación sobre la osteoartritis: los péptidos con colágeno bioactivos estimulan la regeneración de los tejidos de los cartílagos

MONTREAL y KIEL, Alemania, September 14 /PRNewswire/ -- Trabajando en colaboración con la Kiel University, los investigadores del Collagen Research Institute (CRI), con sede en Kiel, han demostrado el efecto estimulador de los péptidos de colágeno bioactivos especiales (FORTIGEL(R)) en el contexto de los experimentos celulares. La semana pasada, el CRI presentó los descubrimientos de sus investigaciones en el Congreso de la Osteoarthritis Research Society International (OARSI) celebrado en Montreal. Las investigaciones del CRI proporcionan una explicación para los descubrimientos en los ensayos clínicos conjuntos realizados en la Harvard Medical School y el Tufts Medical Center, tal y como se han presentado en el congreso. Con la ayuda de las técnicas de imágenes especiales (MRI), este ensayo ha demostrado que el metabolismo celular estimulado FORTIGEL(R) en los cartílagos de las articulaciones de las rodillas y promueve la regeneración del tejido de los cartílagos.

En cooperación con la Kiel University, los investigadores del CRI han aplicado los métodos de biología molecular y química de proteínas directamente en las células, a fin de demostrar el efecto estimulador de FORTIGEL(R). Desarrollado por GELITA AG, este producto contiene una combinación especial de péptidos de colágeno bioactivos de alta pureza. "En todas nuestras investigaciones hemos demostrado que, junto a la síntesis del colágeno de Tipo II - FORTIGEL(R) induce el aumento de producción de aggrecan, un proteoglicanos especial que es de vital importancia para la función de los cartílagos", explicó el doctor Steffen Oesser, director del CRI. Esto proporciona una prueba experimental de que la aplicación de los péptidos de colágeno bioactivos estimula la síntesis renovada de la matriz de los cartílagos extracelulares.

El experimento celular subraya el estudio clínico de Harvard/Tufts

Los experimentos basados en las células del CRI confirman los descubrimientos de los ensayos realizados en la Harvard Medical School y el Tufts Medical Center. El CRI ha demostrado de forma clara a nivel celular que FORTIGEL(R) proporciona un aumento del proteoglicano. Anteriormente, los ensayos clínicos de Harvard/Tufts habían demostrado el efecto regenerativo de FORTIGEL(R) en los cartílagos de las articulaciones de rodilla utilizando la técnica de la imagen de objetivos. Estas dos investigaciones se complementan entre ellas.

El ensayo doble ciego controlado por placebo de Harvard/Tufts reclutó a 30 pacientes diagnosticados con osteoartritis de rodilla, revelando una regeneración destacada del tejido de los cartílagos en el grupo de tratamiento basado en FORTIGEL(R). Dentro del grupo tratado con placebo, la degeneración del cartílago progreso igual que antes.

Para analizar los cambios estructurales en el tejido de los cartílagos, los investigadores de Harvard/Tufts desplegaron una técnica de imagen especial (dGEMRIC). Tras la inyección de un tinte especial en la articulación de la rodilla del paciente es posible determinar la densidad de los proteoglicanos en el cartílago con un alto grado de precisión. Los resultados de este ensayo clínico indican un aumento considerable del proteoglicanos tras la aplicación de FORTIGEL(R). Esto sirve como confirmación clínica de los descubrimientos experimentales del CRI.

Tratamiento de la osteoartritis

"La manipulación prevista del metabolismo del cartílago abre nuevas posibilidades para el tratamiento y la prevención de la osteoartritis", enfatizó el doctor Oesser. Al contrario que los analgésicos y los fármacos antirreumáticos, que apenas alivian los síntomas y efectos, FORTIGEL(R) ofrece el potencial de una terapia alimentaria casual.

Existe una cifra mundial de unos 135 millones de personas que padecen osteoartritis. Los expertos han previsto un rápido aumento de esta cifra, sobre todo en los países industrializados. La prevención de las enfermedades artríticas tiene una prioridad absoluta, principalmente por los elevados costes que supone para los sistemas sanitarios.

Con sede en Kiel/Alemania, el Collagen Research Institute (CRI) se creó en 2003 como organización de investigación independiente. Las actividades del instituto se centran en los cambios degenerativos de los tejidos de conexión y el desarrollo de terapias complementarias y alternativas en el área de la osteoartritis, osteoporosis y cicatrización de heridas. Desde su creación, el CRI ha puesto una atención especial a la investigación de los efectos de los péptidos de colágeno en la matriz extracelular del cartílago articular.

    
    Collagen Research Institute
    Doctor Steffen Oesser
    Tel. +49-(0)431-56-06-610
    Fax  +49-(0)431-56-06-613
    [email protected]

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
The IoTs will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform. In his session at @ThingsExpo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm and share the must-have mindsets for removing complexity from the development proc...
SYS-CON Events announced today that Ericsson has been named “Gold Sponsor” of SYS-CON's @ThingsExpo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. Ericsson is a world leader in the rapidly changing environment of communications technology – providing equipment, software and services to enable transformation through mobility. Some 40 percent of global mobile traffic runs through networks we have supplied. More than 1 billion subscribers around the world re...
You think you know what’s in your data. But do you? Most organizations are now aware of the business intelligence represented by their data. Data science stands to take this to a level you never thought of – literally. The techniques of data science, when used with the capabilities of Big Data technologies, can make connections you had not yet imagined, helping you discover new insights and ask new questions of your data. In his session at @ThingsExpo, Sarbjit Sarkaria, data science team lead ...
SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers’ changing business needs, enabling them to lower costs, improve performance and focus inter...
You deployed your app with the Bluemix PaaS and it's gaining some serious traction, so it's time to make some tweaks. Did you design your application in a way that it can scale in the cloud? Were you even thinking about the cloud when you built the app? If not, chances are your app is going to break. Check out this webcast to learn various techniques for designing applications that will scale successfully in Bluemix, for the confidence you need to take your apps to the next level and beyond.
There is an ever-growing explosion of new devices that are connected to the Internet using “cloud” solutions. This rapid growth is creating a massive new demand for efficient access to data. And it’s not just about connecting to that data anymore. This new demand is bringing new issues and challenges and it is important for companies to scale for the coming growth. And with that scaling comes the need for greater security, gathering and data analysis, storage, connectivity and, of course, the...
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls? In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, will provide tips on how to be successful in large scale machine lear...
SYS-CON Events announced today that Fusion, a leading provider of cloud services, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Fusion, a leading provider of integrated cloud solutions to small, medium and large businesses, is the industry's single source for the cloud. Fusion's advanced, proprietary cloud service platform enables the integration of leading edge solutions in the cloud, including cloud...
In his session at @ThingsExpo, Chris Klein, CEO and Co-founder of Rachio, will discuss next generation communities that are using IoT to create more sustainable, intelligent communities. One example is Sterling Ranch, a 10,000 home development that – with the help of Siemens – will integrate IoT technology into the community to provide residents with energy and water savings as well as intelligent security. Everything from stop lights to sprinkler systems to building infrastructures will run ef...
Digital payments using wearable devices such as smart watches, fitness trackers, and payment wristbands are an increasing area of focus for industry participants, and consumer acceptance from early trials and deployments has encouraged some of the biggest names in technology and banking to continue their push to drive growth in this nascent market. Wearable payment systems may utilize near field communication (NFC), radio frequency identification (RFID), or quick response (QR) codes and barcodes...
The increasing popularity of the Internet of Things necessitates that our physical and cognitive relationship with wearable technology will change rapidly in the near future. This advent means logging has become a thing of the past. Before, it was on us to track our own data, but now that data is automatically available. What does this mean for mHealth and the "connected" body? In her session at @ThingsExpo, Lisa Calkins, CEO and co-founder of Amadeus Consulting, will discuss the impact of wea...
SYS-CON Events announced today that DatacenterDynamics has been named “Media Sponsor” of SYS-CON's 18th International Cloud Expo, which will take place on June 7–9, 2016, at the Javits Center in New York City, NY. DatacenterDynamics is a brand of DCD Group, a global B2B media and publishing company that develops products to help senior professionals in the world's most ICT dependent organizations make risk-based infrastructure and capacity decisions.
The IoT has the potential to create a renaissance of manufacturing in the US and elsewhere. In his session at 18th Cloud Expo, Florent Solt, CTO and chief architect of Netvibes, will discuss how the expected exponential increase in the amount of data that will be processed, transported, stored, and accessed means there will be a huge demand for smart technologies to deliver it. Florent Solt is the CTO and chief architect of Netvibes. Prior to joining Netvibes in 2007, he co-founded Rift Technol...
We’ve worked with dozens of early adopters across numerous industries and will debunk common misperceptions, which starts with understanding that many of the connected products we’ll use over the next 5 years are already products, they’re just not yet connected. With an IoT product, time-in-market provides much more essential feedback than ever before. Innovation comes from what you do with the data that the connected product provides in order to enhance the customer experience and optimize busi...
SYS-CON Events announced today that Stratoscale, the software company developing the next generation data center operating system, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Stratoscale is revolutionizing the data center with a zero-to-cloud-in-minutes solution. With Stratoscale’s hardware-agnostic, Software Defined Data Center (SDDC) solution to store everything, run anything and scale everywhere...
Angular 2 is a complete re-write of the popular framework AngularJS. Programming in Angular 2 is greatly simplified – now it's a component-based well-performing framework. This immersive one-day workshop at 18th Cloud Expo, led by Yakov Fain, a Java Champion and a co-founder of the IT consultancy Farata Systems and the product company SuranceBay, will provide you with everything you wanted to know about Angular 2.
SYS-CON Events announced today that Men & Mice, the leading global provider of DNS, DHCP and IP address management overlay solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. The Men & Mice Suite overlay solution is already known for its powerful application in heterogeneous operating environments, enabling enterprises to scale without fuss. Building on a solid range of diverse platform support,...
Whether your IoT service is connecting cars, homes, appliances, wearable, cameras or other devices, one question hangs in the balance – how do you actually make money from this service? The ability to turn your IoT service into profit requires the ability to create a monetization strategy that is flexible, scalable and working for you in real-time. It must be a transparent, smoothly implemented strategy that all stakeholders – from customers to the board – will be able to understand and comprehe...
Increasing IoT connectivity is forcing enterprises to find elegant solutions to organize and visualize all incoming data from these connected devices with re-configurable dashboard widgets to effectively allow rapid decision-making for everything from immediate actions in tactical situations to strategic analysis and reporting. In his session at 18th Cloud Expo, Shikhir Singh, Senior Developer Relations Manager at Sencha, will discuss how to create HTML5 dashboards that interact with IoT devic...
Artificial Intelligence has the potential to massively disrupt IoT. In his session at 18th Cloud Expo, AJ Abdallat, CEO of Beyond AI, will discuss what the five main drivers are in Artificial Intelligence that could shape the future of the Internet of Things. AJ Abdallat is CEO of Beyond AI. He has over 20 years of management experience in the fields of artificial intelligence, sensors, instruments, devices and software for telecommunications, life sciences, environmental monitoring, process...