Welcome!

Open Source Authors: Plutora Blog, Liz McMillan, Carmen Gonzalez, Lori MacVittie, Yeshim Deniz

News Feed Item

Importante paso adelante en la investigación sobre la osteoartritis

- Importante paso adelante en la investigación sobre la osteoartritis: los péptidos con colágeno bioactivos estimulan la regeneración de los tejidos de los cartílagos

MONTREAL y KIEL, Alemania, September 14 /PRNewswire/ -- Trabajando en colaboración con la Kiel University, los investigadores del Collagen Research Institute (CRI), con sede en Kiel, han demostrado el efecto estimulador de los péptidos de colágeno bioactivos especiales (FORTIGEL(R)) en el contexto de los experimentos celulares. La semana pasada, el CRI presentó los descubrimientos de sus investigaciones en el Congreso de la Osteoarthritis Research Society International (OARSI) celebrado en Montreal. Las investigaciones del CRI proporcionan una explicación para los descubrimientos en los ensayos clínicos conjuntos realizados en la Harvard Medical School y el Tufts Medical Center, tal y como se han presentado en el congreso. Con la ayuda de las técnicas de imágenes especiales (MRI), este ensayo ha demostrado que el metabolismo celular estimulado FORTIGEL(R) en los cartílagos de las articulaciones de las rodillas y promueve la regeneración del tejido de los cartílagos.

En cooperación con la Kiel University, los investigadores del CRI han aplicado los métodos de biología molecular y química de proteínas directamente en las células, a fin de demostrar el efecto estimulador de FORTIGEL(R). Desarrollado por GELITA AG, este producto contiene una combinación especial de péptidos de colágeno bioactivos de alta pureza. "En todas nuestras investigaciones hemos demostrado que, junto a la síntesis del colágeno de Tipo II - FORTIGEL(R) induce el aumento de producción de aggrecan, un proteoglicanos especial que es de vital importancia para la función de los cartílagos", explicó el doctor Steffen Oesser, director del CRI. Esto proporciona una prueba experimental de que la aplicación de los péptidos de colágeno bioactivos estimula la síntesis renovada de la matriz de los cartílagos extracelulares.

El experimento celular subraya el estudio clínico de Harvard/Tufts

Los experimentos basados en las células del CRI confirman los descubrimientos de los ensayos realizados en la Harvard Medical School y el Tufts Medical Center. El CRI ha demostrado de forma clara a nivel celular que FORTIGEL(R) proporciona un aumento del proteoglicano. Anteriormente, los ensayos clínicos de Harvard/Tufts habían demostrado el efecto regenerativo de FORTIGEL(R) en los cartílagos de las articulaciones de rodilla utilizando la técnica de la imagen de objetivos. Estas dos investigaciones se complementan entre ellas.

El ensayo doble ciego controlado por placebo de Harvard/Tufts reclutó a 30 pacientes diagnosticados con osteoartritis de rodilla, revelando una regeneración destacada del tejido de los cartílagos en el grupo de tratamiento basado en FORTIGEL(R). Dentro del grupo tratado con placebo, la degeneración del cartílago progreso igual que antes.

Para analizar los cambios estructurales en el tejido de los cartílagos, los investigadores de Harvard/Tufts desplegaron una técnica de imagen especial (dGEMRIC). Tras la inyección de un tinte especial en la articulación de la rodilla del paciente es posible determinar la densidad de los proteoglicanos en el cartílago con un alto grado de precisión. Los resultados de este ensayo clínico indican un aumento considerable del proteoglicanos tras la aplicación de FORTIGEL(R). Esto sirve como confirmación clínica de los descubrimientos experimentales del CRI.

Tratamiento de la osteoartritis

"La manipulación prevista del metabolismo del cartílago abre nuevas posibilidades para el tratamiento y la prevención de la osteoartritis", enfatizó el doctor Oesser. Al contrario que los analgésicos y los fármacos antirreumáticos, que apenas alivian los síntomas y efectos, FORTIGEL(R) ofrece el potencial de una terapia alimentaria casual.

Existe una cifra mundial de unos 135 millones de personas que padecen osteoartritis. Los expertos han previsto un rápido aumento de esta cifra, sobre todo en los países industrializados. La prevención de las enfermedades artríticas tiene una prioridad absoluta, principalmente por los elevados costes que supone para los sistemas sanitarios.

Con sede en Kiel/Alemania, el Collagen Research Institute (CRI) se creó en 2003 como organización de investigación independiente. Las actividades del instituto se centran en los cambios degenerativos de los tejidos de conexión y el desarrollo de terapias complementarias y alternativas en el área de la osteoartritis, osteoporosis y cicatrización de heridas. Desde su creación, el CRI ha puesto una atención especial a la investigación de los efectos de los péptidos de colágeno en la matriz extracelular del cartílago articular.

    
    Collagen Research Institute
    Doctor Steffen Oesser
    Tel. +49-(0)431-56-06-610
    Fax  +49-(0)431-56-06-613
    [email protected]

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
In their session at @ThingsExpo, Shyam Varan Nath, Principal Architect at GE, and Ibrahim Gokcen, who leads GE's advanced IoT analytics, focused on the Internet of Things / Industrial Internet and how to make it operational for business end-users. Learn about the challenges posed by machine and sensor data and how to marry it with enterprise data. They also discussed the tips and tricks to provide the Industrial Internet as an end-user consumable service using Big Data Analytics and Industrial Cloud.
Things are being built upon cloud foundations to transform organizations. This CEO Power Panel at 15th Cloud Expo, moderated by Roger Strukhoff, Cloud Expo and @ThingsExpo conference chair, addressed the big issues involving these technologies and, more important, the results they will achieve. Rodney Rogers, chairman and CEO of Virtustream; Brendan O'Brien, co-founder of Aria Systems, Bart Copeland, president and CEO of ActiveState Software; Jim Cowie, chief scientist at Dyn; Dave Wagstaff, VP and chief architect at BSQUARE Corporation; Seth Proctor, CTO of NuoDB, Inc.; and Andris Gailitis, C...
How do APIs and IoT relate? The answer is not as simple as merely adding an API on top of a dumb device, but rather about understanding the architectural patterns for implementing an IoT fabric. There are typically two or three trends: Exposing the device to a management framework Exposing that management framework to a business centric logic Exposing that business layer and data to end users. This last trend is the IoT stack, which involves a new shift in the separation of what stuff happens, where data lives and where the interface lies. For instance, it's a mix of architectural styles ...
The Industrial Internet revolution is now underway, enabled by connected machines and billions of devices that communicate and collaborate. The massive amounts of Big Data requiring real-time analysis is flooding legacy IT systems and giving way to cloud environments that can handle the unpredictable workloads. Yet many barriers remain until we can fully realize the opportunities and benefits from the convergence of machines and devices with Big Data and the cloud, including interoperability, data security and privacy.
Technology is enabling a new approach to collecting and using data. This approach, commonly referred to as the "Internet of Things" (IoT), enables businesses to use real-time data from all sorts of things including machines, devices and sensors to make better decisions, improve customer service, and lower the risk in the creation of new revenue opportunities. In his General Session at Internet of @ThingsExpo, Dave Wagstaff, Vice President and Chief Architect at BSQUARE Corporation, discuss the real benefits to focus on, how to understand the requirements of a successful solution, the flow of ...
Cloud Expo 2014 TV commercials will feature @ThingsExpo, which was launched in June, 2014 at New York City's Javits Center as the largest 'Internet of Things' event in the world.
"People are a lot more knowledgeable about APIs now. There are two types of people who work with APIs - IT people who want to use APIs for something internal and the product managers who want to do something outside APIs for people to connect to them," explained Roberto Medrano, Executive Vice President at SOA Software, in this SYS-CON.tv interview at Cloud Expo, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
Performance is the intersection of power, agility, control, and choice. If you value performance, and more specifically consistent performance, you need to look beyond simple virtualized compute. Many factors need to be considered to create a truly performant environment. In his General Session at 15th Cloud Expo, Harold Hannon, Sr. Software Architect at SoftLayer, discussed how to take advantage of a multitude of compute options and platform features to make cloud the cornerstone of your online presence.
In this Women in Technology Power Panel at 15th Cloud Expo, moderated by Anne Plese, Senior Consultant, Cloud Product Marketing at Verizon Enterprise, Esmeralda Swartz, CMO at MetraTech; Evelyn de Souza, Data Privacy and Compliance Strategy Leader at Cisco Systems; Seema Jethani, Director of Product Management at Basho Technologies; Victoria Livschitz, CEO of Qubell Inc.; Anne Hungate, Senior Director of Software Quality at DIRECTV, discussed what path they took to find their spot within the technology industry and how do they see opportunities for other women in their area of expertise.
Wearable devices have come of age. The primary applications of wearables so far have been "the Quantified Self" or the tracking of one's fitness and health status. We propose the evolution of wearables into social and emotional communication devices. Our BE(tm) sensor uses light to visualize the skin conductance response. Our sensors are very inexpensive and can be massively distributed to audiences or groups of any size, in order to gauge reactions to performances, video, or any kind of presentation. In her session at @ThingsExpo, Jocelyn Scheirer, CEO & Founder of Bionolux, will discuss ho...
DevOps Summit 2015 New York, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that it is now accepting Keynote Proposals. The widespread success of cloud computing is driving the DevOps revolution in enterprise IT. Now as never before, development teams must communicate and collaborate in a dynamic, 24/7/365 environment. There is no time to wait for long development cycles that produce software that is obsolete at launch. DevOps may be disruptive, but it is essential.
Almost everyone sees the potential of Internet of Things but how can businesses truly unlock that potential. The key will be in the ability to discover business insight in the midst of an ocean of Big Data generated from billions of embedded devices via Systems of Discover. Businesses will also need to ensure that they can sustain that insight by leveraging the cloud for global reach, scale and elasticity.
We’re no longer looking to the future for the IoT wave. It’s no longer a distant dream but a reality that has arrived. It’s now time to make sure the industry is in alignment to meet the IoT growing pains – cooperate and collaborate as well as innovate. In his session at @ThingsExpo, Jim Hunter, Chief Scientist & Technology Evangelist at Greenwave Systems, will examine the key ingredients to IoT success and identify solutions to challenges the industry is facing. The deep industry expertise behind this presentation will provide attendees with a leading edge view of rapidly emerging IoT oppor...
“With easy-to-use SDKs for Atmel’s platforms, IoT developers can now reap the benefits of realtime communication, and bypass the security pitfalls and configuration complexities that put IoT deployments at risk,” said Todd Greene, founder & CEO of PubNub. PubNub will team with Atmel at CES 2015 to launch full SDK support for Atmel’s MCU, MPU, and Wireless SoC platforms. Atmel developers now have access to PubNub’s secure Publish/Subscribe messaging with guaranteed ¼ second latencies across PubNub’s 14 global points-of-presence. PubNub delivers secure communication through firewalls, proxy ser...
The 3rd International Internet of @ThingsExpo, co-located with the 16th International Cloud Expo - to be held June 9-11, 2015, at the Javits Center in New York City, NY - announces that its Call for Papers is now open. The Internet of Things (IoT) is the biggest idea since the creation of the Worldwide Web more than 20 years ago.
Connected devices and the Internet of Things are getting significant momentum in 2014. In his session at Internet of @ThingsExpo, Jim Hunter, Chief Scientist & Technology Evangelist at Greenwave Systems, examined three key elements that together will drive mass adoption of the IoT before the end of 2015. The first element is the recent advent of robust open source protocols (like AllJoyn and WebRTC) that facilitate M2M communication. The second is broad availability of flexible, cost-effective storage designed to handle the massive surge in back-end data in a world where timely analytics is e...
"There is a natural synchronization between the business models, the IoT is there to support ,” explained Brendan O'Brien, Co-founder and Chief Architect of Aria Systems, in this SYS-CON.tv interview at the 15th International Cloud Expo®, held Nov 4–6, 2014, at the Santa Clara Convention Center in Santa Clara, CA.
The Internet of Things will put IT to its ultimate test by creating infinite new opportunities to digitize products and services, generate and analyze new data to improve customer satisfaction, and discover new ways to gain a competitive advantage across nearly every industry. In order to help corporate business units to capitalize on the rapidly evolving IoT opportunities, IT must stand up to a new set of challenges. In his session at @ThingsExpo, Jeff Kaplan, Managing Director of THINKstrategies, will examine why IT must finally fulfill its role in support of its SBUs or face a new round of...
The BPM world is going through some evolution or changes where traditional business process management solutions really have nowhere to go in terms of development of the road map. In this demo at 15th Cloud Expo, Kyle Hansen, Director of Professional Services at AgilePoint, shows AgilePoint’s unique approach to dealing with this market circumstance by developing a rapid application composition or development framework.
The Internet of Things will greatly expand the opportunities for data collection and new business models driven off of that data. In her session at @ThingsExpo, Esmeralda Swartz, CMO of MetraTech, discussed how for this to be effective you not only need to have infrastructure and operational models capable of utilizing this new phenomenon, but increasingly service providers will need to convince a skeptical public to participate. Get ready to show them the money!